Dangerous Drug Interactions: Pills Plus Juice Don’t Mix

Researchers recently found that subjects who took an antihistamine with grapefruit juice absorbed only half the drug, compared to those who took the pill with water.

“Common juices like grapefruit, apple and orange juice can substantially impede the absorption of drugs into the body,” says David Bailey, professor of medicine, physiology and pharmacology at the University of Western Ontario in London.

And he should know. Nearly 20 years ago, it was Bailey who discovered that grapefruit juice can boost the effects of some other drugs and actually cause toxic overdoses. So, when it’s time to pop that pill, good old H20 is the only way to go.